Solubility and Bioavailability Enhancement of Oridonin: A Review
Identifieur interne : 000047 ( an2020/Analysis ); précédent : 000046; suivant : 000048Solubility and Bioavailability Enhancement of Oridonin: A Review
Auteurs : Yuanyuan Zhang ; Shaohua Wang ; Mengmeng Dai ; Jijuan Nai ; Liqiao Zhu ; Huagang ShengSource :
- Molecules [ 1420-3049 ] ; 2020.
Abstract
Oridonin (ORI), an ent-kaurene tetracyclic diterpenoid compound, is isolated from Chinese herb
Url:
DOI: 10.3390/molecules25020332
PubMed: 31947574
PubMed Central: 7024198
Affiliations:
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PMC:7024198Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Solubility and Bioavailability Enhancement of Oridonin: A Review</title><author><name sortKey="Zhang, Yuanyuan" sort="Zhang, Yuanyuan" uniqKey="Zhang Y" first="Yuanyuan" last="Zhang">Yuanyuan Zhang</name></author><author><name sortKey="Wang, Shaohua" sort="Wang, Shaohua" uniqKey="Wang S" first="Shaohua" last="Wang">Shaohua Wang</name></author><author><name sortKey="Dai, Mengmeng" sort="Dai, Mengmeng" uniqKey="Dai M" first="Mengmeng" last="Dai">Mengmeng Dai</name></author><author><name sortKey="Nai, Jijuan" sort="Nai, Jijuan" uniqKey="Nai J" first="Jijuan" last="Nai">Jijuan Nai</name></author><author><name sortKey="Zhu, Liqiao" sort="Zhu, Liqiao" uniqKey="Zhu L" first="Liqiao" last="Zhu">Liqiao Zhu</name></author><author><name sortKey="Sheng, Huagang" sort="Sheng, Huagang" uniqKey="Sheng H" first="Huagang" last="Sheng">Huagang Sheng</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31947574</idno><idno type="pmc">7024198</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024198</idno><idno type="RBID">PMC:7024198</idno><idno type="doi">10.3390/molecules25020332</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000A74</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A74</idno><idno type="wicri:Area/Pmc/Curation">000A74</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A74</idno><idno type="wicri:Area/Pmc/Checkpoint">000042</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000042</idno><idno type="wicri:Area/Ncbi/Merge">000E41</idno><idno type="wicri:Area/Ncbi/Curation">000E41</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E41</idno><idno type="wicri:Area/Main/Merge">000047</idno><idno type="wicri:Area/Main/Curation">000047</idno><idno type="wicri:Area/Main/Exploration">000047</idno><idno type="wicri:Area/an2020/Extraction">000047</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Solubility and Bioavailability Enhancement of Oridonin: A Review</title><author><name sortKey="Zhang, Yuanyuan" sort="Zhang, Yuanyuan" uniqKey="Zhang Y" first="Yuanyuan" last="Zhang">Yuanyuan Zhang</name></author><author><name sortKey="Wang, Shaohua" sort="Wang, Shaohua" uniqKey="Wang S" first="Shaohua" last="Wang">Shaohua Wang</name></author><author><name sortKey="Dai, Mengmeng" sort="Dai, Mengmeng" uniqKey="Dai M" first="Mengmeng" last="Dai">Mengmeng Dai</name></author><author><name sortKey="Nai, Jijuan" sort="Nai, Jijuan" uniqKey="Nai J" first="Jijuan" last="Nai">Jijuan Nai</name></author><author><name sortKey="Zhu, Liqiao" sort="Zhu, Liqiao" uniqKey="Zhu L" first="Liqiao" last="Zhu">Liqiao Zhu</name></author><author><name sortKey="Sheng, Huagang" sort="Sheng, Huagang" uniqKey="Sheng H" first="Huagang" last="Sheng">Huagang Sheng</name></author></analytic><series><title level="j">Molecules</title><idno type="eISSN">1420-3049</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Oridonin (ORI), an ent-kaurene tetracyclic diterpenoid compound, is isolated from Chinese herb <italic>Rabdosia rubescens</italic> with various biological and pharmacological activities including anti-tumor, anti-microbial and anti-inflammatory effects. However, the clinical application of ORI is limited due to its low solubility and poor bioavailability. In order to overcome these shortcomings, many strategies have been explored such as structural modification, new dosage form, etc. This review provides a detailed discussion on the research progress to increase the solubility and bioavailability of ORI.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Osawa, K" uniqKey="Osawa K">K. Osawa</name></author><author><name sortKey="Yasuda, H" uniqKey="Yasuda H">H. Yasuda</name></author><author><name sortKey="Maruyama, T" uniqKey="Maruyama T">T. Maruyama</name></author><author><name sortKey="Morita, H" uniqKey="Morita H">H. Morita</name></author><author><name sortKey="Takeya, K" uniqKey="Takeya K">K. Takeya</name></author><author><name sortKey="Itokawa, H" uniqKey="Itokawa H">H. 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Xu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Dai, Mengmeng" sort="Dai, Mengmeng" uniqKey="Dai M" first="Mengmeng" last="Dai">Mengmeng Dai</name><name sortKey="Nai, Jijuan" sort="Nai, Jijuan" uniqKey="Nai J" first="Jijuan" last="Nai">Jijuan Nai</name><name sortKey="Sheng, Huagang" sort="Sheng, Huagang" uniqKey="Sheng H" first="Huagang" last="Sheng">Huagang Sheng</name><name sortKey="Wang, Shaohua" sort="Wang, Shaohua" uniqKey="Wang S" first="Shaohua" last="Wang">Shaohua Wang</name><name sortKey="Zhang, Yuanyuan" sort="Zhang, Yuanyuan" uniqKey="Zhang Y" first="Yuanyuan" last="Zhang">Yuanyuan Zhang</name><name sortKey="Zhu, Liqiao" sort="Zhu, Liqiao" uniqKey="Zhu L" first="Liqiao" last="Zhu">Liqiao Zhu</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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